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In conclusion, although hop extract and especially 8-PN are promising candidates as a relief for climacteric symptoms, data on the safety and efficacy is still scarce.

Menopause Comparison of the in vitro estrogenic activities of compounds from hops plant (Humulus lupulus) and red clover (Trifolium pratense). 2005 Because the prevailing form of hormone replacement therapy is associated with the development of cancer in breast and endometrial tissues, alternatives are needed for the management of menopausal symptoms.

Results: There were no differences between active treatments or ibuprofen control in Cox-2 inhibitory action, as indicated by 9-hour Cox-2 Area over the Inhibition Curve (AOC); however, hops powder or hops resin extract produced a 9-hour Cox-1 / Cox-2 AOC ratio of about 0.4 (i.e., some degree of Cox-1 sparing), compared to 1.5 for ibuprofen (i.e. Hops exhibited Cox-2 inhibition over 9 hours equivalent to ibuprofen 400 mg but had significant Cox-1 sparing activity relative to ibuprofen.

Hops extracts may represent a safe alternative to ibuprofen for non-prescription anti-inflammation.

Anti-inflammatory An interesting study listed below discusses the ability of compounds in hops plant to act as COX-2 inhibitors just like some of the new arthritis drugs Vioxx and Celebrex which may make hops plant a potential therapy in cases of arthritis. In particular it would be of interest to determine whether any botanical anti-inflammatory has Cox-1-sparing activity, in order to reduce the risk of gastrointestinal side effects.

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