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After providing guidelines on how to conduct Tukey HSD, Scheffé, Bonferroni and Holm pairwise multiple comparison by hand in Excel, this site provides R code with a tutorial on how to repeat and reproduce the results provided in this calculator using R.

Users unfamiliar with the R statistical package are encouraged to follow this tutorial and not only learn some basic R, but also become grandmasters of harnessing a complex modern statistical package to conduct Tukey HSD, Scheffé, Bonferroni and Holm pairwise multiple comparison.

If ANOVA indicates statistical significance, this calculator automatically performs pairwise post-hoc Tukey HSD, Scheffé, Bonferroni and Holm multiple comparison of all treatments (columns).

Excel has the necessary built-in statistical functions to conduct Scheffé, Bonferroni and Holm multiple comparison from first principles.

This calculator is designed to relieve biomedical scientists from the travails of coding heavy-duty statistical packages: Are you a biomedical or social scientist, who has narrow interest in one-way ANOVA followed automatically by post-hoc Tukey HSD, Scheffé, Bonferroni and Holm methods, but do not have the patience and perseverence to hack code to harness R, Stata, SPSS, SAS or Matlab? It was inspired by the frustration of several biomedical scientists with learning the software setup and coding of these serious statistical packages, almost like operating heavy bulldozer machinery to swat an irritating mosquito.